Avascular necrosis of the femur head in adults has been associated with a variety of disease entities. It is usually recognized as a potential complication of trauma or systemic corticosteroid therapy and chronic alcoholism. We present an unusual case of avascular necrosis in a patient who had many risk factors. A 61-year-old woman with known chronic lymphocytic leukemia in remission for 6 years and who had used metilprednisolon for autoimmune hemolytic anemia for 5 months was admitted to the hospital for a severe right hip pain, difficulty in walking and high fever. We have isolated Salmonella enteritidis from blood cultures. MR imaging and scintigraphy showed avascular necrosis of the femoral head. By conventional treatment of the decompression of femoral head and specific antimicrobial therapy, the patient survived. She has had common risk factors because of the underlying disease and medical approach to avascular necrosis of the femoral head and Salmonella enteritidis bacteremia. This case has been presented to emphasize the rare comorbity of these situations and differential diagnosis.