Effect of levamisole in steroid dependent nephrotic syndrome

Perhaps more importantly, levamisole has been extremely productive in forward genetic screens. In the earliest studies tetramisole was used ( Brenner, 1974 ) and later this was replaced by the more active isomer, levamisole ( Lewis et al., 1980 ). These screens have provided a resource of mutants that have been used over the last two decades to assign function to genes expressed at the neuromuscular junction. Some of these are nACh receptor subunits, but others interestingly are not and serve to either regulate nicotinic receptors or muscle function (see Table 2 ).

In 2007, Michael Munro, a Scottish neonatologist at Aberdeen Maternity Hospital, was cleared of malpractice by the GMC Fitness to Practice panel after giving 23 times the standard dose of pancuronium to two dying neonates . In the final minutes of life, each baby was suffering from agonal gasping and violent body spasms, which was highly distressing for the parents to witness. Munro administered pancuronium to the babies after advising the parents that this would ease their suffering and could also hasten death. [3] [4] It is on record that neither of the children's parents was unhappy with Dr Munro's treatment of their babies. [5]

Levamisole was originally used as an anthelmintic to treat worm infestations in both humans and animals. Levamisole works as a nicotinic acetylcholine receptor agonist that causes continued stimulation of the parasitic worm muscles, leading to paralysis. In countries that still permit the use of levamisole, the recommended dose for anthelmintic therapy is a single dose, with a repeated dose 7 days later if needed for a severe hookworm infection. [8] Most current commercial preparations are intended for veterinary use as a dewormer in cattle, pigs, and sheep. However, levamisole has also recently gained prominence among aquarists as an effective treatment for Camallanus roundworm infestations in freshwater tropical fish . [9]

Effect of levamisole in steroid dependent nephrotic syndrome

effect of levamisole in steroid dependent nephrotic syndrome

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