Dexamethasone is well absorbed when given by mouth; peak plasma levels are reached between 1 and 2 hours after ingestion and show wide interindividual variations. The mean plasma half life is ± . Dexamethasone is bound (to about 77%) to plasma proteins , mainly albumins. Percentage protein binding of dexamethasone, unlike that of cortisol, remains practically unchanged with increasing steroid concentrations. Corticosteroids are rapidly distributed to all body tissues. Dexamethasone is metabolised mainly in the liver but also in the kidney. Dexamethasone and its metabolites are excreted in the urine.
I’m an adult (47) and just got diagnosed with pertussis and am taking antibiotics. I just wanted to add that the antibiotics really helped! I still sound the same, but my throat feels much much better; I had the “tickle” in the throat that is listed as a symptom (which I think contributes to the gagging and throwing up people get!), in my case I thought maybe I had a feather lodged in my throat, so “tickle” it was not! That symptom which had been there a week, was gone almost 100% within maybe 20 hours of being on the antibiotic. I’m not all clear of the cough, so obviously I’m hoping my healing trajectory will continue. I just wanted to say I felt the antibiotics were extremely helpful and I’m so glad I didn’t wait any longer. Also, of course I do not want to be contagious to anyone else. There are sometimes when I’m so grateful for western medicine, this was one time. I’m also using peppermint, eucalyptus, and tea tree oil, which really helps a lot. For a kid it might sting so a lot of carrier oil would be great. Also I’ve been drinking throat comfort herbal tea, which really helps keep the cough calm. Thanks for the article!