Main article: Six Paths Sage Mode Six Paths Sage Mode ( 六道仙人モード , Rikudō Sennin Mōdo ) is a form which empowers the user's abilities to a far greater extent by utilising the Six Paths Sage Chakra . It is a divine state gifted by Hagoromo Ōtsutsuki to those who have an iron faith and the guts to never give up.  The one consistent hallmark of Six Paths Sage Mode are Naruto's eyes: his eyes are yellow, his pupils are a cross of vertical fox -slits with horizontal toad -slats, and there is no pigmentation around his eyes that would otherwise signify standard Sage Mode . 
When trying to augmenting anaesthesia, whether prompted by voluntary movements or myocloni, you soon find out that an additional dose of etomidate does not offer much help, although it prolongs anaesthesia. Other IV anaesthetics do both. I have explained this as an aspect of ‘ceiling effect,’ a concept which to my knowledge has not been used by others. Only combination (potentiating) with certain other drugs will also augment the anaesthetic quality [Figure 2]. Although this phenomenon was occasionally disturbing, until finding out how to deal with it, it can also be regarded an aspect of safety.